Omar Reiss been working on a patch to make WordPress fit with modern modular JavaScript programming practices, and he writes more in depth about this on the Make WordPress Blog.
Omar shows off an overview of the directory structure that comes with the patch, along with the reasons behind his approach. His goal is to do a “much better job at creating a seamless development experience for WordPress core.” Omar is looking for feedback, so be sure to share your thoughts if you do any testing. It will be interesting to see how this effort progresses.